Lecithin retinol acyltransferase

BE0000900ProteinHumansLRAT

Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters (PubMed:9920938). It is acted on by 3 drugs in DrugBank.

Gene name
LRAT
UniProtKB entry
O95237Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
230 residues · 25,703 Da
Also known as
2.3.1.135 · Phosphatidylcholine--retinol O-acyltransferase

Resolves to

Protein
UniProtO95237UniProt nameLRAT_HUMAN
Gene
HGNCHGNC:6685NCBI Gene9227GenBank4240391GeneCardsLRAT
Pharmacology
KEGGhsa:9227
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
11GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
19+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Lecithin retinol acyltransferase, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In