Growth factor receptor-bound protein 2

BE0000917ProteinHumansGRB2

Non-enzymatic adapter protein that plays a pivotal role in precisely regulated signaling cascades from cell surface receptors to cellular responses, including signaling transduction and gene expression (PubMed:11016927, PubMed:11726515, PubMed:37626338). It is acted on by 3 drugs in DrugBank.

Gene name
GRB2
UniProtKB entry
P62993Swiss-Prot
Cellular location
Nucleus
Residues / weight
217 residues · 25,206 Da
Also known as
Adapter protein GRB2 · ASH · Protein Ash · SH2/SH3 adapter GRB2

Resolves to

Protein
UniProtP62993UniProt nameGRB2_HUMAN
Gene
HGNCHGNC:4566NCBI Gene2885GenBank181976GeneCardsGRB2
Pharmacology
KEGGhsa:2885
Structure
PDB1AZEPDB1BM2PDB1BMB
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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26GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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82+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Growth factor receptor-bound protein 2, how selective are they, and which programs against it are still in active trials?

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