C-X-C motif chemokine 10

BE0000934ProteinHumansCXCL10

Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (PubMed:11157474, PubMed:22652417, PubMed:7540647). It is acted on by 4 drugs in DrugBank.

Gene name
CXCL10
UniProtKB entry
P02778Swiss-Prot
Cellular location
Secreted
Residues / weight
98 residues · 10,881 Da
Also known as
10 kDa interferon gamma-induced protein · Gamma-IP10 · INP10 · IP-10 · SCYB10

Resolves to

Protein
UniProtP02778UniProt nameCXL10_HUMAN
Gene
HGNCHGNC:10637NCBI Gene3627GenBank33918GeneCardsCXCL10
Pharmacology
KEGGhsa:3627
Structure
PDB1LV9PDB1O7YPDB1O7Z
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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11Clinical trialsTrials of drugs acting on it, by phase and status
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on C-X-C motif chemokine 10, how selective are they, and which programs against it are still in active trials?

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