Platelet basic protein

BE0000946ProteinHumansPPBP

LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It is acted on by 3 drugs in DrugBank.

Gene name
PPBP
UniProtKB entry
P02775Swiss-Prot
Cellular location
Secreted
Residues / weight
128 residues · 13,894 Da
Also known as
C-X-C motif chemokine 7 · CTAP3 · CXCL7 · LDGF · Leukocyte-derived growth factor

Resolves to

Protein
UniProtP02775UniProt nameCXCL7_HUMAN
Gene
HGNCHGNC:9240NCBI Gene5473GenBank181176GeneCardsPPBP
Pharmacology
KEGGhsa:5473
Structure
PDB1F9PPDB1NAPPDB1TVX
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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27+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Platelet basic protein, how selective are they, and which programs against it are still in active trials?

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