Tumor necrosis factor receptor superfamily member 1B

BE0000949ProteinHumansTNFRSF1B

Receptor with high affinity for TNFSF2/TNF and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. It is acted on by 1 drug in DrugBank.

Gene name
TNFRSF1B
UniProtKB entry
P20333Swiss-Prot
Cellular location
Cell membrane
Residues / weight
461 residues · 48,291 Da
Also known as
p75 · p80 TNF-alpha receptor · TNF-R2 · TNF-RII · TNFBR

Resolves to

Protein
UniProtP20333UniProt nameTNR1B_HUMAN
Gene
HGNCHGNC:11917NCBI Gene7133GenBank189186GeneCardsTNFRSF1B
Pharmacology
KEGGhsa:7133
Structure
PDB1CA9PDB3ALQPDB8HLB
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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20GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tumor necrosis factor receptor superfamily member 1B, how selective are they, and which programs against it are still in active trials?

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