Phosphatidylinositol 3-kinase regulatory subunit alpha

Details

Name
Phosphatidylinositol 3-kinase regulatory subunit alpha
Kind
protein
Synonyms
  • GRB1
  • Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha
  • PI3-kinase regulatory subunit alpha
  • PI3-kinase subunit p85-alpha
  • PI3K regulatory subunit alpha
  • PtdIns-3-kinase regulatory subunit alpha
  • PtdIns-3-kinase regulatory subunit p85-alpha
Gene Name
PIK3R1
UniProtKB Entry
P27986Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0001901|Phosphatidylinositol 3-kinase regulatory subunit alpha
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAE
QFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTPSVDLEMIDVH
VLADAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTL
QYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNE
RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIID
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR
Number of residues
724
Molecular Weight
83597.675
Theoretical pI
6.06
GO Classification
Functions
1-phosphatidylinositol-3-kinase regulator activity / ErbB-3 class receptor binding / insulin binding / insulin receptor binding / insulin receptor substrate binding / insulin-like growth factor receptor binding / neurotrophin TRKA receptor binding / phosphatidylinositol 3-kinase binding / phosphatidylinositol 3-kinase regulator activity / protein phosphatase binding / transmembrane receptor protein tyrosine kinase adaptor activity
Processes
B cell differentiation / cellular response to insulin stimulus / cellular response to UV / extrinsic apoptotic signaling pathway via death domain receptors / growth hormone receptor signaling pathway / insulin receptor signaling pathway / insulin-like growth factor receptor signaling pathway / intrinsic apoptotic signaling pathway in response to DNA damage / negative regulation of apoptotic process / negative regulation of cell-matrix adhesion / negative regulation of osteoclast differentiation / positive regulation of endoplasmic reticulum unfolded protein response / positive regulation of glucose import / positive regulation of RNA splicing / positive regulation of tumor necrosis factor production / protein stabilization / response to endoplasmic reticulum stress
Components
cell-cell junction / cis-Golgi network / cytoplasm / cytosol / membrane / nucleus / perinuclear endoplasmic reticulum membrane / phosphatidylinositol 3-kinase complex / phosphatidylinositol 3-kinase complex, class IA / plasma membrane
General Function
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923)
Specific Function
1-phosphatidylinositol-3-kinase regulator activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0021657|Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)
ATGCATGGTGATTATACTCTTACACTAAGGAAAGGGGGAAATAACAAATTAATCAAAATA
TTTCATCGAGATGGGAAATATGGCTTCTCTGACCCATTAACCTTCAGTTCTGTGGTTGAA
TTAATAAACCACTACCGGAATGAATCTCTAGCTCAGTATAATCCCAAATTGGATGTGAAA
TTACTTTATCCAGTATCCAAATACCAACAGGATCAAGTTGTCAAAGAAGATAATATTGAA
GCTGTAGGGAAAAAATTACATGAATATAACACTCAGTTTCAAGAAAAAAGTCGAGAATAT
GATAGATTATATGAAGAATATACCCGCACATCCCAGGAAATCCAAATGAAAAGGACAGCT
ATTGAAGCATTTAATGAAACCATAAAAATATTTGAAGAACAGTGCCAGACCCAAGAGCGG
TACAGCAAAGAATACATAGAAAAGTTTAAACGTGAAGGCAATGAGAAAGAAATACAAAGG
ATTATGCATAATTATGATAAGTTGAAGTCTCGAATCAGTGAAATTATTGACAGTAGAAGA
AGATTGGAAGAAGACTTGAAGAAGCAGGCAGCTGAGTATCGAGAAATTGACAAACGTATG
AACAGCATTAAACCAGACCTTATCCAGCTGAGAAAGACGAGAGACCAATACTTGATGTGG
TTGACTCAAAAAGGTGTTCGGCAAAAGAAGTTGAACGAGTGGTTGGGCAATGAAAACACT
GAAGACCAATATTCACTGGTGGAAGATGATGAAGATTTGCCCCATCATGATGAGAAGACA
TGGAATGTTGGAAGCAGCAACCGAAACAAAGCTGAAAACCTGTTGCGAGGGAAGCGAGAT
GGCACTTTTCTTGTCCGGGAGAGCAGTAAACAGGGCTGCTATGCCTGCTCTGTAGTGGTG
GACGGCGAAGTAAAGCATTGTGTCATAAACAAAACAGCAACTGGCTATGGCTTTGCCGAG
CCCTATAACTTGTACAGCTCTCTGAAAGAACTGGTGCTACATTACCAACACACCTCCCTT
GTGCAGCACAACGACTCCCTCAATGTCACACTAGCCTACCCAGTATATGCACAGCAGAGG
CGATGA
Chromosome Location
5
Locus
5q13.1
External Identifiers
ResourceLink
UniProtKB IDP27986
UniProtKB Entry NameP85A_HUMAN
GenBank Gene IDM61906
GeneCard IDPIK3R1
GenAtlas IDPIK3R1
HGNC IDHGNC:8979
PDB ID(s)1A0N, 1AZG, 1H9O, 1PBW, 1PHT, 1PIC, 1PKS, 1PKT, 2IUG, 2IUH, 2IUI, 2RD0, 2V1Y, 3HHM, 3HIZ, 3I5R, 3I5S, 4A55, 4JPS, 4L1B, 4L23, 4L2Y, 4OVU, 4OVV, 4WAF, 4YKN, 4ZOP, 5AUL, 5FI4, 5GJI, 5ITD, 5M6U, 5SW8, 5SWG, 5SWO, 5SWP, 5SWR, 5SWT, 5SX8, 5SX9, 5SXA, 5SXB, 5SXC, 5SXD, 5SXE, 5SXF, 5SXI, 5SXJ, 5SXK, 5UBT, 5UK8, 5UKJ, 5UL1, 5VLR, 5XGH, 5XGI, 5XGJ, 6NCT, 6PYR, 6PYU, 7CIO, 7LM2, 7LQ1, 7MYN, 7MYO, 7PG5, 7PG6, 7RNS, 7TZ7, 8AM0, 8DCP, 8DCX, 8DD4, 8DD8, 8GUB, 8H36, 8H37, 8ILR, 8ILS, 8ILV, 8SBC, 8SBJ, 8TDU, 8TGD, 8TS7, 8TS8, 8TS9, 8TSA, 8TSB, 8TSC, 8TSD, 8TU6, 8V8H, 8V8I, 8V8J, 8V8U, 8V8V, 8W9A, 8W9B
KEGG IDhsa:5295
NCBI Gene ID5295
General References
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
SF1126investigationalunknowntargetDetails
EnzastaurininvestigationalunknowntargetDetails
WortmanninexperimentalunknowntargetDetails