Phosphatidylinositol 3-kinase regulatory subunit alpha

BE0000955ProteinHumansPIK3R1

Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. It is acted on by 3 drugs in DrugBank.

Gene name
PIK3R1
UniProtKB entry
P27986Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
724 residues · 83,598 Da
Also known as
GRB1 · Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha · PI3-kinase regulatory subunit alpha · PI3-kinase subunit p85-alpha · PI3K regulatory subunit alpha

Resolves to

Protein
UniProtP27986UniProt nameP85A_HUMAN
Gene
HGNCHGNC:8979NCBI Gene5295GeneCardsPIK3R1
Pharmacology
KEGGhsa:5295
Structure
PDB1A0NPDB1AZGPDB1H9O
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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31GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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63+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Phosphatidylinositol 3-kinase regulatory subunit alpha, and which indications are they being tested in?

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