Eukaryotic translation initiation factor 4E

BE0000957ProteinHumansEIF4E

Acts in the cytoplasm to initiate and regulate protein synthesis and is required in the nucleus for export of a subset of mRNAs from the nucleus to the cytoplasm which promotes processes such as RNA... It is acted on by 5 drugs in DrugBank.

Gene name
EIF4E
UniProtKB entry
P06730Swiss-Prot
Cellular location
Cytoplasm, P-body
Residues / weight
217 residues · 25,097 Da
Also known as
eIF-4E · eIF-4F 25 kDa subunit · eIF4E · EIF4EL1 · EIF4F

Resolves to

Protein
UniProtP06730UniProt nameIF4E_HUMAN
Gene
HGNCHGNC:3287NCBI Gene1977GenBank306487GeneCardsEIF4E
Pharmacology
KEGGhsa:1977
Structure
PDB1IPBPDB1IPCPDB1WKW
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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39+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Eukaryotic translation initiation factor 4E, and which indications are they being tested in?

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