Spermine synthase

BE0000964ProteinHumansSMS

Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM). It is acted on by 1 drug in DrugBank.

Gene name
SMS
UniProtKB entry
P52788Swiss-Prot
Residues / weight
366 residues · 41,268 Da
Also known as
2.5.1.22 · Spermidine aminopropyltransferase · SPMSY

Resolves to

Protein
UniProtP52788UniProt nameSPSY_HUMAN
Gene
HGNCHGNC:11123NCBI Gene6611GenBank791051GeneCardsSMS
Pharmacology
KEGGhsa:6611
Structure
PDB3C6KPDB3C6M
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Spermine synthase, and which indications are they being tested in?

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