Tissue factor pathway inhibitor

BE0000967ProteinHumansTFPI

Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It is acted on by 6 drugs in DrugBank.

Gene name
TFPI
UniProtKB entry
P10646Swiss-Prot
Cellular location
Secreted
Residues / weight
304 residues · 35,015 Da
Also known as
EPI · Extrinsic pathway inhibitor · LACI · Lipoprotein-associated coagulation inhibitor · TFPI

Resolves to

Protein
UniProtP10646UniProt nameTFPI1_HUMAN
Gene
HGNCHGNC:11760NCBI Gene7035GenBank180546GeneCardsTFPI
Pharmacology
KEGGhsa:7035
Structure
PDB1ADZPDB1IRHPDB1TFX
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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43+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tissue factor pathway inhibitor, how selective are they, and which programs against it are still in active trials?

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