Insulin-like growth factor-binding protein 3

BE0000970ProteinHumansIGFBP3

Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type... It is acted on by 3 drugs in DrugBank.

Gene name
IGFBP3
UniProtKB entry
P17936Swiss-Prot
Cellular location
Secreted
Residues / weight
291 residues · 31,674 Da
Also known as
IBP-3 · IBP3 · IGF-binding protein 3 · IGFBP-3

Resolves to

Protein
UniProtP17936UniProt nameIBP3_HUMAN
Gene
HGNCHGNC:5472NCBI Gene3486GenBank183116GeneCardsIGFBP3
Pharmacology
KEGGhsa:3486
Structure
PDB7WRQ
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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11Clinical trialsTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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24+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Insulin-like growth factor-binding protein 3, how selective are they, and which programs against it are still in active trials?

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