Insulin receptor substrate 1

BE0000977ProteinHumansIRS1

Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:7541045, PubMed:33991522, PubMed:38625937). It is acted on by 3 drugs in DrugBank.

Gene name
IRS1
UniProtKB entry
P35568Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
1,242 residues · 131,590 Da
Also known as
IRS-1

Resolves to

Protein
UniProtP35568UniProt nameIRS1_HUMAN
Gene
HGNCHGNC:6125NCBI Gene3667GenBank246466GeneCardsIRS1
Pharmacology
KEGGhsa:3667
Structure
PDB1IRSPDB1K3APDB1QQG
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
9GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
38+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Insulin receptor substrate 1, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In