Tyrosine-protein phosphatase non-receptor type 4

BE0000980ProteinHumansPTPN4

Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis (PubMed:25825441, PubMed:27246854). It is acted on by 1 drug in DrugBank.

Gene name
PTPN4
UniProtKB entry
P29074Swiss-Prot
Cellular location
Cell membrane
Residues / weight
926 residues · 105,910 Da
Also known as
3.1.3.48 · MEG · Protein-tyrosine phosphatase MEG1 · PTPase-MEG1

Resolves to

Protein
UniProtP29074UniProt namePTN4_HUMAN
Gene
HGNCHGNC:9656NCBI Gene5775GenBank190748GeneCardsPTPN4
Pharmacology
KEGGhsa:5775
Structure
PDB2CS5PDB2I75PDB2VPH
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tyrosine-protein phosphatase non-receptor type 4, how selective are they, and which programs against it are still in active trials?

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