Parkinson disease protein 7

BE0000992ProteinHumansPARK7

Multifunctional protein with controversial molecular function which plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease (PubMed:12796482, PubMed:17015834, PubMed:18711745, PubMed:19229105, PubMed:20304780,... It is acted on by 1 drug in DrugBank.

Gene name
PARK7
UniProtKB entry
Q99497Swiss-Prot
Cellular location
Cell membrane
Residues / weight
189 residues · 19,891 Da
Also known as
DJ-1 · Maillard deglycase · Oncogene DJ1 · Parkinsonism-associated deglycase · Protein DJ-1

Resolves to

Protein
UniProtQ99497UniProt namePARK7_HUMAN
Gene
HGNCHGNC:16369NCBI Gene11315GenBank30038760GeneCardsPARK7
Pharmacology
KEGGhsa:11315
Structure
PDB1J42PDB1P5FPDB1PDV
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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41GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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48+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Parkinson disease protein 7, how selective are they, and which programs against it are still in active trials?

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