N-formyl peptide receptor 1

BE0000995ProteinHumansFPR1

Pattern recognition G protein-coupled receptor (PRR/GPCR) involved in innate recognition of N-formyl-methionyl peptides derived from invading microbes and host mitochondria as pathogen- and damage-associated molecular patterns (PAMPs and DAMPs). It is acted on by 2 drugs in DrugBank.

Gene name
FPR1
UniProtKB entry
P21462Swiss-Prot
Cellular location
Cell membrane
Residues / weight
350 residues · 38,445 Da
Also known as
fMet-Leu-Phe receptor · fMLP receptor · N-formylpeptide chemoattractant receptor

Resolves to

Protein
UniProtP21462UniProt nameFPR1_HUMAN
Gene
HGNCHGNC:3826NCBI Gene2357GenBank189184GeneCardsFPR1
Pharmacology
IUPHAR/GtoPdb222KEGGhsa:2357
Structure
PDB7EUOPDB7T6TPDB7VFX
Drugs

What you can answer from here — as of June 05, 2026

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on N-formyl peptide receptor 1, how selective are they, and which programs against it are still in active trials?

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