Glycine--tRNA ligase

BE0000998ProteinHumansGARS1

Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:17544401, PubMed:24898252, PubMed:28675565). It is acted on by 1 drug in DrugBank.

Gene name
GARS1
UniProtKB entry
P41250Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
739 residues · 83,165 Da
Also known as
6.1.1.14 · Ap4A synthetase · Diadenosine tetraphosphate synthetase · GARS · Glycyl-tRNA synthetase

Resolves to

Protein
UniProtP41250UniProt nameGARS_HUMAN
Gene
HGNCHGNC:4162NCBI Gene2617GenBank1311463GeneCardsGARS1
Pharmacology
KEGGhsa:2617
Structure
PDB2PMEPDB2PMFPDB2Q5H
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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24+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glycine--tRNA ligase, how selective are they, and which programs against it are still in active trials?

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