Platelet glycoprotein Ib alpha chain

BE0001025ProteinHumansGP1BA

GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium. It is acted on by 5 drugs in DrugBank.

Gene name
GP1BA
UniProtKB entry
P07359Swiss-Prot
Cellular location
Membrane
Residues / weight
652 residues · 71,539 Da
Also known as
Antigen CD42b-alpha · Glycoprotein Ibalpha · GP-Ib alpha · GPIb-alpha · GPIbA

Resolves to

Protein
UniProtP07359UniProt nameGP1BA_HUMAN
Gene
HGNCHGNC:4439NCBI Gene2811GenBank306793GeneCardsGP1BA
Pharmacology
KEGGhsa:2811
Structure
PDB1GWBPDB1M0ZPDB1M10
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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37+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Platelet glycoprotein Ib alpha chain, how selective are they, and which programs against it are still in active trials?

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