Basement membrane-specific heparan sulfate proteoglycan core protein

BE0001031ProteinHumansHSPG2

Integral component of basement membranes. It is acted on by 3 drugs in DrugBank.

Gene name
HSPG2
UniProtKB entry
P98160Swiss-Prot
Cellular location
Secreted, extracellular space, extracellular matrix, basement membrane
Residues / weight
4,391 residues · 468,826 Da
Also known as
HSPG · Perlecan · PLC

Resolves to

Protein
UniProtP98160UniProt namePGBM_HUMAN
Gene
HGNCHGNC:5273NCBI Gene3339GenBank29470GeneCardsHSPG2
Pharmacology
KEGGhsa:3339
Structure
PDB3SH4PDB3SH5
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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30+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Basement membrane-specific heparan sulfate proteoglycan core protein, how selective are they, and which programs against it are still in active trials?

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