Transcription factor Jun

BE0001040ProteinHumansJUN

Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed:10995748, PubMed:22083952). It is acted on by 9 drugs in DrugBank.

Gene name
JUN
UniProtKB entry
P05412Swiss-Prot
Cellular location
Nucleus
Residues / weight
331 residues · 35,675 Da
Also known as
Activator protein 1 · AP1 · p39 · Proto-oncogene c-Jun · Transcription factor AP-1 subunit Jun

Resolves to

Protein
UniProtP05412UniProt nameJUN_HUMAN
Gene
HGNCHGNC:6204NCBI Gene3725GenBank386839GeneCardsJUN
Pharmacology
KEGGhsa:3725
Structure
PDB1A02PDB1FOSPDB1JNM
Drugs

What you can answer from here — as of September 03, 2024

9DrugsApproved to experimental, with action, bond type and pharmacological action
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5Clinical trialsTrials of drugs acting on it, by phase and status
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34GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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52+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Transcription factor Jun, how selective are they, and which programs against it are still in active trials?

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