Integrin beta-2

BE0001041ProteinHumansITGB2

Integrin ITGAL:ITGB2 is a receptor for ICAM1, ICAM2 and ICAM3 (PubMed:1676048, PubMed:23775590, PubMed:38195629). It is acted on by 2 drugs in DrugBank.

Gene name
ITGB2
UniProtKB entry
P05107Swiss-Prot
Cellular location
Cell membrane
Residues / weight
769 residues · 84,790 Da
Also known as
CD18 · Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta · Complement receptor C3 subunit beta · MFI7

Resolves to

Protein
UniProtP05107UniProt nameITB2_HUMAN
Gene
HGNCHGNC:6155NCBI Gene3689GenBank307113GeneCardsITGB2
Pharmacology
IUPHAR/GtoPdb2456KEGGhsa:3689
Structure
PDB1L3YPDB1YUKPDB2JF1
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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36GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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30+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Integrin beta-2, and which indications are they being tested in?

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