6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

BE0001073ProteinHumansPFKFB1

Synthesis and degradation of fructose 2,6-bisphosphate. It is acted on by 6 drugs in DrugBank.

Gene name: PFKFB1
UniProtKB entry: P16118Swiss-Prot
Residues / weight: 471 residues · 54,681 Da
Also known as: 6PF-2-K/Fru-2,6-P2ase 1 · 6PF-2-K/Fru-2,6-P2ase liver isozyme · F6PK · PFK/FBPase 1 · PFRX

Resolves to

Protein

UniProtP16118UniProt nameF261_HUMAN

Gene

HGNCHGNC:8872NCBI Gene5207GenBank35503GeneCardsPFKFB1

Pharmacology

KEGGhsa:5207

Structure

PDB1K6M

Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action

10GO termsFunction, process and component, as structured annotations

2Pfam domainsDomain architecture mapped to Pfam families and clans

14+ReferencesStructured and connected to the statements they support

Which approved drugs act on 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1, how selective are they, and which programs against it are still in active trials?

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