85/88 kDa calcium-independent phospholipase A2

BE0001077ProteinHumansPLA2G6

Calcium-independent phospholipase involved in phospholipid remodeling with implications in cellular membrane homeostasis, mitochondrial integrity and signal transduction. It is acted on by 1 drug in DrugBank.

Gene name
PLA2G6
UniProtKB entry
O60733Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
806 residues · 89,902 Da
Also known as
2-lysophosphatidylcholine acylhydrolase · 3.1.1.4 · CaI-PLA2 · Group VI phospholipase A2 · GVI PLA2

Resolves to

Protein
UniProtO60733UniProt namePLPL9_HUMAN
Gene
HGNCHGNC:9039NCBI Gene8398GenBank3142700GeneCardsPLA2G6
Pharmacology
KEGGhsa:8398
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 85/88 kDa calcium-independent phospholipase A2, and which indications are they being tested in?

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