Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

BE0001080ProteinHumansGNG2

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems (PubMed:29925951, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:35714614, PubMed:35835867, PubMed:36087581, PubMed:36989299, PubMed:37327704, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:38168118, PubMed:38552625, PubMed:39103320). It is acted on by 1 drug in DrugBank.

Gene name
GNG2
UniProtKB entry
P59768Swiss-Prot
Cellular location
Cell membrane
Residues / weight
71 residues · 7,850 Da
Also known as
G gamma-I

Resolves to

Protein
UniProtP59768UniProt nameGBG2_HUMAN
Gene
HGNCHGNC:4404NCBI Gene54331GenBank20147633GeneCardsGNG2
Pharmacology
KEGGhsa:54331
Structure
PDB20YCPDB21AGPDB21DU
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, how selective are they, and which programs against it are still in active trials?

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