Lymphotoxin-alpha

BE0001087ProteinHumansLTA

Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (PubMed:9462508). It is acted on by 2 drugs in DrugBank.

Gene name
LTA
UniProtKB entry
P01374Swiss-Prot
Cellular location
Secreted
Residues / weight
205 residues · 22,297 Da
Also known as
LT-alpha · TNF-beta · TNFB · TNFSF1 · Tumor necrosis factor ligand superfamily member 1

Resolves to

Protein
UniProtP01374UniProt nameTNFB_HUMAN
Gene
HGNCHGNC:6709NCBI Gene4049GenBank34445GeneCardsLTA
Pharmacology
KEGGhsa:4049
Structure
PDB1TNRPDB4MXVPDB4MXW
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Lymphotoxin-alpha, how selective are they, and which programs against it are still in active trials?

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