Phosphatidylserine synthase 1

BE0001099ProteinHumansPTDSS1

Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:19014349, PubMed:24241535). It is acted on by 1 drug in DrugBank.

Gene name
PTDSS1
UniProtKB entry
P48651Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
473 residues · 55,527 Da
Also known as
2.7.8.29 · KIAA0024 · PSS-1 · PSSA · PtdSer synthase 1

Resolves to

Protein
UniProtP48651UniProt namePTSS1_HUMAN
Gene
HGNCHGNC:9587NCBI Gene9791GenBank603802GeneCardsPTDSS1
Pharmacology
KEGGhsa:9791
Structure
PDB9B4EPDB9B4FPDB9B4G
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Phosphatidylserine synthase 1, how selective are they, and which programs against it are still in active trials?

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