Bactericidal permeability-increasing protein

BE0001112ProteinHumansBPI

The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are... It is acted on by 1 drug in DrugBank.

Gene name
BPI
UniProtKB entry
P17213Swiss-Prot
Cellular location
Secreted
Residues / weight
487 residues · 53,899 Da
Also known as
BPI · CAP 57

Resolves to

Protein
UniProtP17213UniProt nameBPI_HUMAN
Gene
HGNCHGNC:1095NCBI Gene671GenBank179529GeneCardsBPI
Pharmacology
KEGGhsa:671
Structure
PDB1BP1PDB1EWF
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Bactericidal permeability-increasing protein, and which indications are they being tested in?

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