S-methyl-5'-thioadenosine phosphorylase

BE0001128ProteinHumansMTAP

Catalyzes the phosphorolytic cleavage of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose1-phosphate (PubMed:3091600, PubMed:8687427, PubMed:10404592). It is acted on by 5 drugs in DrugBank.

Gene name
MTAP
UniProtKB entry
Q13126Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
283 residues · 31,236 Da
Also known as
2.4.2.28 · 5'-methylthioadenosine phosphorylase · MSAP · MTA phosphorylase · MTAP

Resolves to

Protein
UniProtQ13126UniProt nameMTAP_HUMAN
Gene
HGNCHGNC:7413NCBI Gene4507GenBank847724GeneCardsMTAP
Pharmacology
KEGGhsa:4507
Structure
PDB1CB0PDB1CG6PDB1K27
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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26+ReferencesStructured and connected to the statements they support
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Which approved drugs act on S-methyl-5'-thioadenosine phosphorylase, how selective are they, and which programs against it are still in active trials?

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