Tumor necrosis factor receptor superfamily member 1A

BE0001139ProteinHumansTNFRSF1A

Receptor for TNFSF2/TNF and homotrimeric TNFSF1/lymphotoxin-alpha. It is acted on by 4 drugs in DrugBank.

Gene name
TNFRSF1A
UniProtKB entry
P19438Swiss-Prot
Cellular location
Cell membrane
Residues / weight
455 residues · 50,494 Da
Also known as
p55 · p60 · TNF-R1 · TNF-RI · TNFAR

Resolves to

Protein
UniProtP19438UniProt nameTNR1A_HUMAN
Gene
HGNCHGNC:11916NCBI Gene7132GenBank37224GeneCardsTNFRSF1A
Pharmacology
KEGGhsa:7132
Structure
PDB1EXTPDB1FT4PDB1ICH
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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6Clinical trialsTrials of drugs acting on it, by phase and status
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20GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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31+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tumor necrosis factor receptor superfamily member 1A, how selective are they, and which programs against it are still in active trials?

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