Geranylgeranyl transferase type-1 subunit beta

BE0001142ProteinHumansPGGT1B

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. It is acted on by 3 drugs in DrugBank.

Gene name
PGGT1B
UniProtKB entry
P53609Swiss-Prot
Residues / weight
377 residues · 42,368 Da
Also known as
2.5.1.59 · Geranylgeranyl transferase type I subunit beta · GGTase-I-beta · Type I protein geranyl-geranyltransferase subunit beta

Resolves to

Protein
UniProtP53609UniProt namePGTB1_HUMAN
Gene
HGNCHGNC:8895NCBI Gene5229GenBank466491GeneCardsPGGT1B
Pharmacology
KEGGhsa:5229
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Geranylgeranyl transferase type-1 subunit beta, and which indications are they being tested in?

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