Deoxyhypusine synthase

BE0001149ProteinHumansDHPS

Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate... It is acted on by 2 drugs in DrugBank.

Gene name
DHPS
UniProtKB entry
P49366Swiss-Prot
Residues / weight
369 residues · 40,970 Da
Also known as
2.5.1.46 · DHS · DS

Resolves to

Protein
UniProtP49366UniProt nameDHYS_HUMAN
Gene
HGNCHGNC:2869NCBI Gene1725GenBank994715GeneCardsDHPS
Pharmacology
KEGGhsa:1725
Structure
PDB1DHSPDB1RLZPDB1ROZ
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5Clinical trialsTrials of drugs acting on it, by phase and status
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Deoxyhypusine synthase, and which indications are they being tested in?

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