Deoxyhypusine synthase
Details
- Name
- Deoxyhypusine synthase
- Kind
- protein
- Synonyms
- 2.5.1.46
- DHS
- DS
- Gene Name
- DHPS
- UniProtKB Entry
- P49366Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0002285|Deoxyhypusine synthase MEGSLEREAPAGALAAVLKHSSTLPPESTQVRGYDFNRGVNYRALLEAFGTTGFQATNFG RAVQQVNAMIEKKLEPLSQDEDQHADLTQSRRPLTSCTIFLGYTSNLISSGIRETIRYLV QHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNENYCKFE DWLMPILDQMVMEQNTEGVKWTPSKMIARLGKEINNPESVYYWAQKNHIPVFSPALTDGS LGDMIFFHSYKNPGLVLDIVEDLRLINTQAIFAKCTGMIILGGGVVKHHIANANLMRNGA DYAVYINTAQEFDGSDSGARPDEAVSWGKIRVDAQPVKVYADASLVFPLLVAETFAQKMD AFMHEKNED
- Number of residues
- 369
- Molecular Weight
- 40970.28
- Theoretical pI
- 5.02
- GO Classification
- Functionsidentical protein bindingProcessespositive regulation of cell population proliferation / spermidine catabolic process / spermidine metabolic processComponentscytoplasm
- General Function
- Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue (PubMed:30661771). This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function
- Specific Function
- deoxyhypusine synthase activity
- Pfam Domain Function
- DS (PF01916)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0010803|Deoxyhypusine synthase (DHPS) ATGCCTATAATCCCAGCATTTTGGGAAGCCGAGGCGGGTGGATCAAGAGAAGAGGAGTTC GAGACAAGCCTGGCCAACATGATCGAGAAGAAGCTGGAACCACTGTCACAGGATGAAGAC CAGCACGCGGACCTGACCCAGAGCCGCCGCCCACTTACCAGCTGCACCATTTTCCTGGGA TATACATCCAACCTCATCAGTTCAGGCATCCGTGAGACCATTCGCTACCTTGTGCAGCAC AACATGGTGGACGTATTGGTGACCACAGCTGGCGGCGTGGAGGAAGACCTCATCAAGTGC CTGGCGCCCACATACTTGGGCGAGTTTAGCCTCAGGGGGAAGGAGCTCCGGGAGAACGGG ATCAATAGGATCGGAAACCTGCTGGTGCCCAATGAGAATTACTGCAAGTTTGAGGACTGG CTGATGCCCATTCTGGACCAGATGGTGATGGAGCAGAACACAGAGGGTGTAAAGTGGACG CCTTCTAAGATGATCGCCCGGCTGGGCAAGGAGATCAACAACCCAGAGTCCGTGTATTAC TGGGCCCAGAAGAACCACATCCCTGTGTTTAGTCCCGCACTTACAGACGGCTCGCTGGGC GACATGATCTTCTTCCATTCCTACAAGAACCCGGGCCTGGTCCTGGACATCGTTGAGGAC CTGAGGCTCATCAACACACAGGCCATCTTTGCCAAGTGCACTGGGATGATCATTCTGGGC GGGGGCGTGGTCAAGCACCACATTGCCAATGCCAACCTCATGCGGAACGGGGCCGACTAC GCTGTTTACATCAACACAGCCCAGGAGTTTGATGGCTCTGACTCAGGTGCCCGACCAGAC GAGGCTGTCTCCTGGGGCAAGATCCGGGTGGATGCACAGCCCGTCAAGGTCTATGCTGAC GCCTCCCTGGTCTTCCCCCTGCTTGTGGCTGAAACCTTTGCCCAGAAGATGGATGCCTTC ATGCATGAGAAGAACGAGGACTGA
- Chromosome Location
- 19
- Locus
- 19p13.13
- External Identifiers
Resource Link UniProtKB ID P49366 UniProtKB Entry Name DHYS_HUMAN GenBank Protein ID 994715 GenBank Gene ID L39068 GeneCard ID DHPS GenAtlas ID DHPS HGNC ID HGNC:2869 PDB ID(s) 1DHS, 1RLZ, 1ROZ, 1RQD, 6P4V, 6PGR, 6WKZ, 6WL6, 6XXH, 6XXI, 6XXJ, 6XXK, 6XXL, 6XXM, 7A6S, 7A6T, 8A0E, 8A0F, 8A0G KEGG ID hsa:1725 NCBI Gene ID 1725 - General References
- Joe YA, Wolff EC, Park MH: Cloning and expression of human deoxyhypusine synthase cDNA. Structure-function studies with the recombinant enzyme and mutant proteins. J Biol Chem. 1995 Sep 22;270(38):22386-92. [Article]
- Bevec D, Kappel B, Jaksche H, Csonga R, Hauber J, Klier H, Steinkasserer A: Molecular characterization of a cDNA encoding functional human deoxyhypusine synthase and chromosomal mapping of the corresponding gene locus. FEBS Lett. 1996 Jan 8;378(2):195-8. [Article]
- Yan YP, Tao Y, Chen KY: Molecular cloning and functional expression of human deoxyhypusine synthase cDNA based on expressed sequence tag information. Biochem J. 1996 Apr 15;315 ( Pt 2):429-34. [Article]
- Mantuano E, Trettel F, Olsen AS, Lennon G, Frontali M, Jodice C: Localization and genomic structure of human deoxyhypusine synthase gene on chromosome 19p13.2-distal 19p13.1. Gene. 1998 Jul 17;215(1):153-7. [Article]
- Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA: Large-scale concatenation cDNA sequencing. Genome Res. 1997 Apr;7(4):353-8. [Article]
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- Klier H, Csonga R, Steinkasserer A, Wohl T, Lottspeich F, Eder J: Purification and characterization of human deoxyhypusine synthase from HeLa cells. FEBS Lett. 1995 May 8;364(2):207-10. [Article]
- Joe YA, Wolff EC, Lee YB, Park MH: Enzyme-substrate intermediate at a specific lysine residue is required for deoxyhypusine synthesis. The role of Lys329 in human deoxyhypusine synthase. J Biol Chem. 1997 Dec 19;272(51):32679-85. [Article]
- Lee CH, Um PY, Park MH: Structure-function studies of human deoxyhypusine synthase: identification of amino acid residues critical for the binding of spermidine and NAD. Biochem J. 2001 May 1;355(Pt 3):841-9. [Article]
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- Liao DI, Wolff EC, Park MH, Davies DR: Crystal structure of the NAD complex of human deoxyhypusine synthase: an enzyme with a ball-and-chain mechanism for blocking the active site. Structure. 1998 Jan 15;6(1):23-32. [Article]
- Umland TC, Wolff EC, Park MH, Davies DR: A new crystal structure of deoxyhypusine synthase reveals the configuration of the active enzyme and of an enzyme.NAD.inhibitor ternary complex. J Biol Chem. 2004 Jul 2;279(27):28697-705. Epub 2004 Apr 20. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 1-Guanidinium-7-Aminoheptane experimental unknown target inhibitor Details