14-3-3 protein zeta/delta

BE0001174ProteinHumansYWHAZ

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). It is acted on by 1 drug in DrugBank.

Gene name
YWHAZ
UniProtKB entry
P63104Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
245 residues · 27,745 Da
Also known as
KCIP-1 · Protein kinase C inhibitor protein 1

Resolves to

Protein
UniProtP63104UniProt name1433Z_HUMAN
Gene
HGNCHGNC:12855NCBI Gene7534GenBank189953GeneCardsYWHAZ
Pharmacology
KEGGhsa:7534
Structure
PDB1IB1PDB1QJAPDB1QJB
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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26GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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41+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 14-3-3 protein zeta/delta, and which indications are they being tested in?

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