Prosaposin

BE0001175ProteinHumansPSAP

Saposins are specific low-molecular mass non-enzymatic glycoproteins that act as activator proteins for lysosomal sphingolipid-degrading enzymes, facilitating the hydrolysis of sphingolipids by extracting lipid substrates from membranes and presenting them to their respective enzymes. It is acted on by 4 drugs in DrugBank.

Gene name
PSAP
UniProtKB entry
P07602Swiss-Prot
Cellular location
Lysosome
Residues / weight
524 residues · 58,112 Da
Also known as
GLBA · Proactivator polypeptide · SAP1

Resolves to

Protein
UniProtP07602UniProt nameSAP_HUMAN
Gene
HGNCHGNC:9498NCBI Gene5660GenBank220064GeneCardsPSAP
Pharmacology
KEGGhsa:5660
Structure
PDB1M12PDB1N69PDB1SN6
Drugs

What you can answer from here — as of September 03, 2024

4DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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8GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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49+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Prosaposin, and which indications are they being tested in?

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