Angiogenin

BE0001181ProteinHumansANG

Secreted ribonuclease that can either promote or restrict cell proliferation of target cells, depending on the context (PubMed:12051708, PubMed:1400510, PubMed:19332886, PubMed:20129916, PubMed:21855800, PubMed:23047679, PubMed:23843625, PubMed:2424496, PubMed:2459697, PubMed:2730651, PubMed:27518564, PubMed:28176817, PubMed:29100074, PubMed:29748193, PubMed:3122207, PubMed:32510170, PubMed:38718836, PubMed:8159680,... It is acted on by 2 drugs in DrugBank.

Gene name
ANG
UniProtKB entry
P03950Swiss-Prot
Cellular location
Secreted
Residues / weight
147 residues · 16,550 Da
Also known as
3.1.27.- · Ribonuclease 5 · RNase 5 · RNASE5

Resolves to

Protein
UniProtP03950UniProt nameANGI_HUMAN
Gene
HGNCHGNC:483NCBI Gene283GenBank178250GeneCardsANG
Pharmacology
KEGGhsa:283
Structure
PDB1A4YPDB1ANGPDB1AWZ
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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19GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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35+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Angiogenin, how selective are they, and which programs against it are still in active trials?

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