Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

BE0001205ProteinHumansDUT

Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de... It is acted on by 2 drugs in DrugBank.

Gene name
DUT
UniProtKB entry
P33316Swiss-Prot
Cellular location
Nucleus
Residues / weight
252 residues · 26,563 Da
Also known as
3.6.1.23 · dUTP pyrophosphatase · dUTPase

Resolves to

Protein
UniProtP33316UniProt nameDUT_HUMAN
Gene
HGNCHGNC:3078NCBI Gene1854GenBank2443580GeneCardsDUT
Pharmacology
KEGGhsa:1854
Structure
PDB1Q5HPDB1Q5UPDB24OK
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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2Metabolic reactionsDrug transformations it catalyses, substrate to product
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, and which indications are they being tested in?

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