Thymidylate kinase

BE0001221ProteinHumansDTYMK

Catalyzes the phosphorylation of thymidine monophosphate (dTMP) to thymidine diphosphate (dTDP), the immediate precursor for the DNA building block dTTP, with ATP as the preferred phosphoryl donor in the presence of Mg(2+). It is acted on by 9 drugs in DrugBank.

Gene name
DTYMK
UniProtKB entry
P23919Swiss-Prot
Residues / weight
212 residues · 23,819 Da
Also known as
2.7.4.9 · CDC8 · dTMP kinase · TMPK · TYMK

Resolves to

Protein
UniProtP23919UniProt nameKTHY_HUMAN
Gene
HGNCHGNC:3061NCBI Gene1841GenBank37206GeneCardsDTYMK
Pharmacology
KEGGhsa:1841
Structure
PDB1E2DPDB1E2EPDB1E2F
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
1Metabolic reactionDrug transformations it catalyses, substrate to product
Sign in
1GO termFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
22+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Thymidylate kinase, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In