cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

BE0001223ProteinHumansPDE3B

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process (PubMed:14592490, PubMed:21393242). It is acted on by 5 drugs in DrugBank.

Gene name
PDE3B
UniProtKB entry
Q13370Swiss-Prot
Cellular location
Membrane
Residues / weight
1,112 residues · 124,332 Da
Also known as
3.1.4.17 · CGI-PDE B · CGIP1 · CGIPDE1 · Cyclic GMP-inhibited phosphodiesterase B

Resolves to

Protein
UniProtQ13370UniProt namePDE3B_HUMAN
Gene
HGNCHGNC:8779NCBI Gene5140GenBank1145302GeneCardsPDE3B
Pharmacology
IUPHAR/GtoPdb1299KEGGhsa:5140
Structure
PDB1SO2PDB1SOJPDB8SYC
Drugs

What you can answer from here — as of September 03, 2024

5DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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24+ReferencesStructured and connected to the statements they support
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Which approved drugs act on cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B, how selective are they, and which programs against it are still in active trials?

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