2,3-dihydroxybenzoate-AMP ligase
Details
- Name
- 2,3-dihydroxybenzoate-AMP ligase
- Kind
- protein
- Synonyms
- 6.3.2.-
- Dihydroxybenzoic acid-activating enzyme
- entE
- Gene Name
- dhbE
- UniProtKB Entry
- P40871Swiss-Prot
- Organism
- Bacillus subtilis (strain 168)
- NCBI Taxonomy ID
- 224308
- Amino acid sequence
>lcl|BSEQ0019081|2,3-dihydroxybenzoate-AMP ligase MLKGFTPWPDELAETYRKNGCWAGETFGDLLRDRAAKYGDRIAITCGNTHWSYRELDTRA DRLAAGFQKLGIQQMDRVVVQLPNIKEFFEVIFALFRLGALPVFALPSHRSSEITYFCEF AEAAAYIIPDAYSGFDYRSLARQVQSKLPTLKNIIVAGEAEEFLPLEDLHAEPVKLPEVK SSDVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVCWLDHSTVYLAALPMAHNYPLSS PGVLGVLYAGGRVVLSPSPSPDDAFPLIEREKVTITALVPPLAMVWMDAASSRRDDLSSL QVLQVGGAKFSAEAARRVKAVFGCTLQQVFGMAEGLVNYTRLDDPEEIIVNTQGKPMSPY DEMRVWDDHDRDVKPGETGHLLTRGPYTIRGYYKAEEHNAASFTEDGFYRTGDIVRLTRD GYIVVEGRAKDQINRGGEKVAAEEVENHLLAHPAVHDAAMVSMPDQFLGERSCVFIIPRD EAPKAAELKAFLRERGLAAYKIPDRVEFVESFPQTGVGKVSKKALREAISEKLLAGFKK
- Number of residues
- 539
- Molecular Weight
- 59927.77
- Theoretical pI
- 5.98
- GO Classification
- Functions(2,3-dihydroxybenzoyl)adenylate synthase activity / ATP binding / ligase activityProcessessiderophore biosynthetic processComponentscytoplasm
- General Function
- Involved in the biosynthesis of the catecholic siderophore bacillibactin. Catalyzes the activation of the carboxylate group of 2,3-dihydroxy-benzoate (DHB), via ATP-dependent PPi exchange reactions, to the acyladenylate.
- Specific Function
- 2,3-dihydroxybenzoate--[aryl-carrier protein] ligase
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0019082|2,3-dihydroxybenzoate-AMP ligase (dhbE) ATGCTGAAAGGATTTACGCCTTGGCCTGATGAGTTAGCTGAGACCTATCGAAAGAACGGC TGCTGGGCCGGTGAGACGTTTGGAGATTTGTTAAGGGACCGGGCAGCCAAATATGGTGAT CGCATTGCCATTACATGCGGAAACACCCATTGGAGCTATCGAGAGCTTGACACAAGGGCT GATCGCCTGGCTGCCGGATTTCAAAAGCTCGGCATTCAACAGATGGATCGTGTTGTGGTG CAGTTGCCAAATATCAAAGAGTTTTTTGAAGTCATTTTCGCGCTTTTCCGTCTGGGGGCG CTTCCAGTCTTCGCACTGCCTTCTCATCGAAGCAGTGAAATTACATATTTTTGCGAGTTT GCTGAAGCGGCTGCATATATCATTCCCGACGCTTATTCCGGTTTTGACTACCGTTCGCTT GCCAGACAGGTTCAAAGCAAGCTGCCGACTTTGAAAAACATCATTGTCGCAGGTGAGGCA GAGGAATTTTTACCGCTGGAGGATTTGCATGCAGAACCTGTAAAACTGCCTGAAGTCAAA TCATCGGATGTGGCGTTCCTCCAGCTTTCTGGCGGGAGCACCGGGCTATCGAAACTGATT CCGAGGACCCACGATGACTACATATACAGCCTGAAGCGGAGTGTGGAGGTCTGCTGGCTC GACCACAGCACGGTGTACTTGGCCGCGCTGCCGATGGCACACAATTATCCGCTGAGCTCA CCCGGCGTTCTCGGCGTATTATACGCTGGAGGAAGAGTGGTATTATCTCCTTCTCCAAGT CCAGATGACGCATTTCCTTTAATTGAACGGGAAAAGGTCACGATAACCGCTCTTGTTCCG CCTCTTGCGATGGTATGGATGGATGCGGCATCCTCACGCCGTGATGATTTATCCAGCCTT CAAGTGCTGCAGGTCGGCGGTGCCAAGTTTAGTGCTGAAGCCGCGCGCAGGGTAAAAGCT GTTTTCGGCTGCACGCTGCAGCAGGTGTTCGGAATGGCAGAGGGTCTCGTCAATTATACG AGATTGGATGATCCTGAGGAGATCATTGTCAACACCCAAGGAAAACCGATGTCTCCATAT GATGAAATGCGTGTTTGGGATGATCATGATCGCGACGTAAAACCTGGTGAAACAGGCCAT CTGCTGACGCGGGGGCCGTATACAATTCGAGGTTACTATAAGGCAGAAGAGCATAACGCC GCTTCATTTACTGAGGACGGTTTTTACCGTACGGGTGATATCGTCAGGCTGACACGAGAC GGCTATATTGTCGTTGAAGGCCGGGCGAAGGATCAAATTAACCGTGGAGGAGAAAAGGTT GCGGCTGAAGAGGTAGAAAATCATCTGCTGGCGCATCCGGCTGTCCATGATGCGGCAATG GTCTCCATGCCTGATCAATTTCTTGGCGAAAGATCTTGTGTGTTCATTATTCCCCGGGAT GAAGCCCCAAAAGCCGCAGAGCTTAAAGCATTTTTGAGAGAGCGCGGACTGGCGGCATAT AAAATCCCTGATCGAGTTGAATTTGTCGAATCCTTCCCGCAGACAGGAGTAGGAAAAGTC AGCAAAAAAGCGCTCCGTGAAGCCATTTCCGAGAAGCTTCTTGCAGGATTTAAAAAATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P40871 UniProtKB Entry Name DHBE_BACSU GenBank Protein ID 837332 GenBank Gene ID U26444 PDB ID(s) 1MD9, 1MDB, 1MDF KEGG ID bsu:BSU31980 NCBI Gene ID 936509 - General References
- Rowland BM, Grossman TH, Osburne MS, Taber HW: Sequence and genetic organization of a Bacillus subtilis operon encoding 2,3-dihydroxybenzoate biosynthetic enzymes. Gene. 1996 Oct 31;178(1-2):119-23. [Article]
- Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. [Article]
- Adams R, Schumann W: Cloning and mapping of the Bacillus subtilis locus homologous to Escherichia coli ent genes. Gene. 1993 Oct 29;133(1):119-21. [Article]
- May JJ, Kessler N, Marahiel MA, Stubbs MT: Crystal structure of DhbE, an archetype for aryl acid activating domains of modular nonribosomal peptide synthetases. Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12120-5. Epub 2002 Sep 9. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 2,3-Dihydroxy-Benzoic Acid experimental unknown target Details