2,3-dihydroxybenzoate-AMP ligase

BE0001232ProteinBacillus subtilis (strain 168)dhbE

Involved in the biosynthesis of the catecholic siderophore bacillibactin. It is acted on by 1 drug in DrugBank.

Gene name
dhbE
UniProtKB entry
P40871Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
539 residues · 59,928 Da
Also known as
6.2.1.71 · 6.3.2.- · Dihydroxybenzoic acid-activating enzyme · entE

Resolves to

Protein
UniProtP40871UniProt nameDHBE_BACSU
Gene
NCBI Gene936509GenBank837332
Pharmacology
KEGGbsu:BSU31980
Structure
PDB1MD9PDB1MDBPDB1MDF
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 2,3-dihydroxybenzoate-AMP ligase, and which indications are they being tested in?

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