Adenylate kinase
Details
- Name
- Adenylate kinase
- Kind
- protein
- Synonyms
- 2.7.4.3
- Adenylate monophosphate kinase
- AK
- ATP-AMP transphosphorylase
- ATP:AMP phosphotransferase
- SOI16
- Superoxide-inducible protein 16
- Gene Name
- adk
- UniProtKB Entry
- P16304Swiss-Prot
- Organism
- Bacillus subtilis (strain 168)
- NCBI Taxonomy ID
- 224308
- Amino acid sequence
>lcl|BSEQ0010862|Adenylate kinase MNLVLMGLPGAGKGTQGERIVEDYGIPHISTGDMFRAAMKEETPLGLEAKSYIDKGELVP DEVTIGIVKERLGKDDCERGFLLDGFPRTVAQAEALEEILEEYGKPIDYVINIEVDKDVL MERLTGRRICSVCGTTYHLVFNPPKTPGICDKDGGELYQRADDNEETVSKRLEVNMKQTQ PLLDFYSEKGYLANVNGQQDIQDVYADVKDLLGGLKK
- Number of residues
- 217
- Molecular Weight
- 24119.24
- Theoretical pI
- 4.38
- GO Classification
- Functionsadenylate kinase activity / ATP binding / metal ion bindingProcessesAMP salvageComponentscytoplasm
- General Function
- Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
- Specific Function
- adenylate kinase activity
- Pfam Domain Function
- ADK_lid (PF05191)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0010863|Adenylate kinase (adk) ATGAACTTAGTCTTAATGGGGCTTCCTGGTGCCGGTAAAGGCACACAGGGCGAACGAATT GTTGAGGATTATGGGATTCCTCATATCTCAACAGGAGATATGTTCCGTGCTGCTATGAAA GAAGAAACACCACTCGGACTCGAAGCAAAATCTTATATTGATAAGGGAGAGCTCGTACCT GACGAAGTCACAATCGGAATTGTAAAAGAGAGACTTGGCAAAGATGATTGTGAAAGAGGT TTTCTTCTGGACGGATTTCCGCGAACAGTCGCTCAAGCCGAAGCTCTTGAAGAAATTCTT GAGGAATACGGCAAGCCGATTGATTATGTCATTAACATTGAAGTCGACAAAGATGTTCTG ATGGAACGTCTGACTGGACGCAGAATTTGCAGTGTTTGCGGCACAACCTATCATTTAGTC TTTAATCCGCCGAAAACGCCGGGTATTTGTGATAAAGACGGAGGCGAACTCTATCAACGG GCAGATGATAATGAGGAAACAGTCTCTAAACGGCTTGAGGTAAACATGAAGCAAACTCAG CCTTTACTCGATTTCTATTCAGAGAAAGGTTATCTTGCAAACGTGAATGGCCAGCAGGAC ATTCAAGACGTTTATGCAGATGTGAAGGATCTTCTTGGAGGATTAAAAAAATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P16304 UniProtKB Entry Name KAD_BACSU GenBank Protein ID 216340 GenBank Gene ID D00619 PDB ID(s) 1P3J, 2EU8, 2OO7, 2ORI, 2OSB, 2P3S, 2QAJ, 3DKV, 3DL0, 4MKF, 4MKG, 4MKH, 4QBF, 4QBG, 4TYP, 4TYQ KEGG ID bsu:BSU01370 NCBI Gene ID 938508 - General References
- Nakamura K, Nakamura A, Takamatsu H, Yoshikawa H, Yamane K: Cloning and characterization of a Bacillus subtilis gene homologous to E. coli secY. J Biochem. 1990 Apr;107(4):603-7. [Article]
- Suh JW, Boylan SA, Oh SH, Price CW: Genetic and transcriptional organization of the Bacillus subtilis spc-alpha region. Gene. 1996 Feb 22;169(1):17-23. [Article]
- Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. [Article]
- Yoshikawa H, Doi RH: Sequence of the Bacillus subtilis spectinomycin resistance gene region. Nucleic Acids Res. 1990 Mar 25;18(6):1647. [Article]
- Suh JW, Boylan SA, Thomas SM, Dolan KM, Oliver DB, Price CW: Isolation of a secY homologue from Bacillus subtilis: evidence for a common protein export pathway in eubacteria. Mol Microbiol. 1990 Feb;4(2):305-14. [Article]
- Antelmann H, Bernhardt J, Schmid R, Mach H, Volker U, Hecker M: First steps from a two-dimensional protein index towards a response-regulation map for Bacillus subtilis. Electrophoresis. 1997 Aug;18(8):1451-63. [Article]
- Glaser P, Presecan E, Delepierre M, Surewicz WK, Mantsch HH, Barzu O, Gilles AM: Zinc, a novel structural element found in the family of bacterial adenylate kinases. Biochemistry. 1992 Mar 31;31(12):3038-43. [Article]
- Bae E, Phillips GN Jr: Structures and analysis of highly homologous psychrophilic, mesophilic, and thermophilic adenylate kinases. J Biol Chem. 2004 Jul 2;279(27):28202-8. Epub 2004 Apr 20. [Article]
- Counago R, Chen S, Shamoo Y: In vivo molecular evolution reveals biophysical origins of organismal fitness. Mol Cell. 2006 May 19;22(4):441-9. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Bis(Adenosine)-5'-Pentaphosphate experimental unknown target Details