ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2

BE0001241ProteinHumansBST1

Catalyzes both the synthesis of cyclic ADP-beta-D-ribose (cADPR) from NAD(+), and its hydrolysis to ADP-D-ribose (ADPR) (PubMed:7805847). It is acted on by 5 drugs in DrugBank.

Gene name
BST1
UniProtKB entry
Q10588Swiss-Prot
Cellular location
Cell membrane
Residues / weight
318 residues · 35,724 Da
Also known as
3.2.2.6 · ADP-ribosyl cyclase 2 · Bone marrow stromal cell antigen 1 · BST-1 · cADPR hydrolase 2

Resolves to

Protein
UniProtQ10588UniProt nameBST1_HUMAN
Gene
HGNCHGNC:1118NCBI Gene683GenBank999429GeneCardsBST1
Pharmacology
KEGGhsa:683
Structure
PDB1ISFPDB1ISGPDB1ISH
Drugs

What you can answer from here — as of September 03, 2024

5DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
4GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
18+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In