2-methylisocitrate lyase

BE0001259ProteinEscherichia coli (strain K12)prpB

Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle I (propionate degradation route). It is acted on by 1 drug in DrugBank.

Gene name
prpB
UniProtKB entry
P77541Swiss-Prot
Residues / weight
296 residues · 32,134 Da
Also known as
(2R,3S)-2-methylisocitrate lyase · 2-MIC · 4.1.3.30 · yahQ

Resolves to

Protein
UniProtP77541UniProt namePRPB_ECOLI
Gene
NCBI Gene944990GenBank1657527
Pharmacology
KEGGecj:JW0323
Structure
PDB1MUMPDB1MZXPDB1OQF
Drugs

What you can answer from here — as of September 04, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 2-methylisocitrate lyase, and which indications are they being tested in?

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