6,7-dimethyl-8-ribityllumazine synthase

BE0001270ProteinMycobacterium tuberculosisribH

Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. It is acted on by 10 drugs in DrugBank.

Gene name
ribH
UniProtKB entry
P9WHE9Swiss-Prot
Residues / weight
160 residues · 16,370 Da
Also known as
2.5.1.78 · DMRL synthase

Resolves to

Protein
UniProtP9WHE9UniProt nameRISB_MYCTU
Gene
NCBI Gene886681
Pharmacology
KEGGmtu:Rv1416
Structure
PDB1W19PDB1W29PDB2C92
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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27+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 6,7-dimethyl-8-ribityllumazine synthase, and which indications are they being tested in?

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