ATP-dependent dethiobiotin synthetase BioD 1

BE0001271ProteinEscherichia coli (strain K12)bioD1

Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. It is acted on by 5 drugs in DrugBank.

Gene name
bioD1
UniProtKB entry
P13000Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
225 residues · 24,139 Da
Also known as
6.3.3.3 · Dethiobiotin synthase · Dethiobiotin synthase 1 · DTB synthetase 1 · DTBS 1

Resolves to

Protein
UniProtP13000UniProt nameBIOD1_ECOLI
Gene
NCBI Gene945387GenBank145427
Pharmacology
KEGGecj:JW0761
Structure
PDB1A82PDB1BS1PDB1BYI
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which compounds in development act on ATP-dependent dethiobiotin synthetase BioD 1, and which indications are they being tested in?

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