2,3-diketo-L-gulonate reductase

BE0001272ProteinEscherichia coli (strain K12)dlgD

Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate. It is acted on by 1 drug in DrugBank.

Gene name
dlgD
UniProtKB entry
P37672Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
332 residues · 36,572 Da
Also known as
1.1.1.130 · 2,3-DKG reductase · 3-dehydro-L-gulonate 2-dehydrogenase · yiaK

Resolves to

Protein
UniProtP37672UniProt nameDLGD_ECOLI
Gene
NCBI Gene948096GenBank466713
Pharmacology
KEGGecj:JW3547
Structure
PDB1NXUPDB1S20
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 2,3-diketo-L-gulonate reductase, and which indications are they being tested in?

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