2,3-diketo-L-gulonate reductase
Details
- Name
- 2,3-diketo-L-gulonate reductase
- Kind
- protein
- Synonyms
- 1.1.1.130
- 2,3-DKG reductase
- 3-dehydro-L-gulonate 2-dehydrogenase
- yiaK
- Gene Name
- dlgD
- UniProtKB Entry
- P37672Swiss-Prot
- Organism
- Escherichia coli (strain K12)
- NCBI Taxonomy ID
- 83333
- Amino acid sequence
>lcl|BSEQ0019092|2,3-diketo-L-gulonate reductase MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGD IIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRG GSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSY GMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLL SDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAI RLPGHEFTTLLAENRRNGITVDDSVWAKIQAL
- Number of residues
- 332
- Molecular Weight
- 36572.395
- Theoretical pI
- 4.97
- GO Classification
- Functions3-dehydro-L-gulonate 2-dehydrogenase activity / NAD+ binding / oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptorComponentscytoplasm
- General Function
- Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate.
- Specific Function
- 3-dehydro-L-gulonate 2-dehydrogenase activity
- Pfam Domain Function
- Ldh_2 (PF02615)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0019093|2,3-diketo-L-gulonate reductase (dlgD) ATGAAAGTGACATTTGAGCAGTTAAAAGCAGCCTTTAATCGGGTCTTAATTTCACGCGGC GTTGACAGCGAAACGGCTGACGCCTGTGCAGAGATGTTCGCCCGCACCACCGAATCCGGC GTTTATTCTCACGGCGTTAATCGTTTCCCTCGTTTCATTCAACAACTGGAAAACGGCGAT ATCATTCCTGATGCCCAACCCAAACGTATAACCAGCCTCGGCGCAATTGAACAGTGGGAC GCCCAGCGTTCGATCGGTAACCTGACAGCGAAAAAGATGATGGATCGCGCCATTGAACTG GCTGCCGATCACGGTATTGGTCTGGTGGCACTACGTAATGCCAACCACTGGATGCGCGGC GGCAGCTACGGCTGGCAGGCGGCGGAAAAAGGCTATATTGGCATTTGCTGGACCAACTCC ATCGCCGTAATGCCGCCGTGGGGCGCAAAAGAGTGTCGCATAGGCACTAACCCGCTGATC GTCGCCATTCCTTCCACGCCGATCACCATGGTCGATATGTCGATGTCGATGTTCTCTTAC GGCATGTTAGAAGTTAACCGTCTGGCAGGTCGTCAGCTCCCGGTCGATGGTGGCTTTGAT GATGAGGGCAATTTGACCAAAGAACCTGGCGTTATCGAGAAGAATCGCCGCATTTTGCCG ATGGGCTACTGGAAAGGTTCTGGCATGTCGATTGTGCTGGATATGATCGCTACTCTCCTT TCCGACGGCGCATCCGTTGCCGAAGTCACCCAGGACAACAGCGACGAATACGGCATTTCA CAAATTTTTATTGCCATTGAAGTGGACAAGCTTATCGACGGTCCCACCCGCGATGCCAAG CTGCAACGCATCATGGATTACGTTACTAGTGCCGAGCGTGCTGACGAAAATCAGGCCATT CGCTTACCCGGCCATGAATTTACTACCCTGCTGGCCGAAAACCGCCGTAACGGCATCACT GTTGATGACAGCGTGTGGGCCAAAATCCAGGCGTTATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P37672 UniProtKB Entry Name DLGD_ECOLI GenBank Protein ID 466713 GenBank Gene ID U00039 PDB ID(s) 1NXU, 1S20 KEGG ID ecj:JW3547 NCBI Gene ID 948096 - General References
- Sofia HJ, Burland V, Daniels DL, Plunkett G 3rd, Blattner FR: Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes. Nucleic Acids Res. 1994 Jul 11;22(13):2576-86. [Article]
- Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [Article]
- Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [Article]
- Badia J, Ibanez E, Sabate M, Baldoma L, Aguilar J: A rare 920-kilobase chromosomal inversion mediated by IS1 transposition causes constitutive expression of the yiaK-S operon for carbohydrate utilization in Escherichia coli. J Biol Chem. 1998 Apr 3;273(14):8376-81. [Article]
- Yew WS, Gerlt JA: Utilization of L-ascorbate by Escherichia coli K-12: assignments of functions to products of the yjf-sga and yia-sgb operons. J Bacteriol. 2002 Jan;184(1):302-6. [Article]
- Forouhar F, Lee I, Benach J, Kulkarni K, Xiao R, Acton TB, Montelione GT, Tong L: A novel NAD-binding protein revealed by the crystal structure of 2,3-diketo-L-gulonate reductase (YiaK). J Biol Chem. 2004 Mar 26;279(13):13148-55. Epub 2004 Jan 12. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details D-tartaric acid experimental unknown target Details