Pleckstrin homology domain-containing family A member 4

BE0001278ProteinHumansPLEKHA4

Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides. It is acted on by 1 drug in DrugBank.

Gene name
PLEKHA4
UniProtKB entry
Q9H4M7Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
779 residues · 85,400 Da
Also known as
PEPP-1 · PEPP1 · PH domain-containing family A member 4 · Phosphoinositol 3-phosphate-binding protein 1

Resolves to

Protein
UniProtQ9H4M7UniProt namePKHA4_HUMAN
Gene
HGNCHGNC:14339NCBI Gene57664GenBank9992893GeneCardsPLEKHA4
Pharmacology
KEGGhsa:57664
Structure
PDB1UPQPDB1UPRPDB8OIO
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
1GO termFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
5+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Pleckstrin homology domain-containing family A member 4, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In