Delta-aminolevulinic acid dehydratase

BE0001285ProteinPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)hemB

Catalyzes an early step in the biosynthesis of tetrapyrroles. It is acted on by 2 drugs in DrugBank.

Gene name
hemB
UniProtKB entry
Q59643Swiss-Prot
Residues / weight
337 residues · 37,037 Da
Also known as
4.2.1.24 · ALAD · Porphobilinogen synthase

Resolves to

Protein
UniProtQ59643UniProt nameHEM2_PSEAE
Gene
NCBI Gene879701GenBank1009431
Pharmacology
KEGGpae:PA5243
Structure
PDB1B4KPDB1GZGPDB1W54
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Delta-aminolevulinic acid dehydratase, how selective are they, and which programs against it are still in active trials?

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