Triggering receptor expressed on myeloid cells 1

BE0001288ProteinHumansTREM1

Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses (PubMed:10799849, PubMed:21393102). It is acted on by 3 drugs in DrugBank.

Gene name
TREM1
UniProtKB entry
Q9NP99Swiss-Prot
Cellular location
Cell membrane
Residues / weight
234 residues · 26,386 Da
Also known as
TREM-1 · Triggering receptor expressed on monocytes 1

Resolves to

Protein
UniProtQ9NP99UniProt nameTREM1_HUMAN
Gene
HGNCHGNC:17760NCBI Gene54210GenBank8050527GeneCardsTREM1
Pharmacology
KEGGhsa:54210
Structure
PDB1Q8MPDB1SMO
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Triggering receptor expressed on myeloid cells 1, and which indications are they being tested in?

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