Triggering receptor expressed on myeloid cells 1
Details
- Name
- Triggering receptor expressed on myeloid cells 1
- Kind
- protein
- Synonyms
- TREM-1
- Triggering receptor expressed on monocytes 1
- Gene Name
- TREM1
- UniProtKB Entry
- Q9NP99Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0002562|Triggering receptor expressed on myeloid cells 1 MRKTRLWGLLWMLFVSELRAATKLTEEKYELKEGQTLDVKCDYTLEKFASSQKAWQIIRD GEMPKTLACTERPSKNSHPVQVGRIILEDYHDHGLLRVRMVNLQVEDSGLYQCVIYQPPK EPHMLFDRIRLVVTKGFSGTPGSNENSTQNVYKIPPTTTKALCPLYTSPRTVTQAPPKST ADVSTPDSEINLTNVTDIIRVPVFNIVILLAGGFLSKSLVFSVLFAVTLRSFVP
- Number of residues
- 234
- Molecular Weight
- 26386.385
- Theoretical pI
- 9.13
- GO Classification
- Functionsreceptor decoy activity / signaling receptor activity / transmembrane signaling receptor activityProcessesadaptive immune response / neutrophil-mediated killing of gram-negative bacteriumComponentscell surface / extracellular space
- General Function
- Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses (PubMed:10799849, PubMed:21393102). Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12 (PubMed:17568691, PubMed:25595774, PubMed:29568119). In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma (PubMed:14656437, PubMed:21659545). This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections (PubMed:17098818, PubMed:17568691). By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis (PubMed:11323674, PubMed:21393102)
- Specific Function
- receptor decoy activity
- Pfam Domain Function
- Not Available
- Signal Regions
- 1-20
- Transmembrane Regions
- 206-226
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0016375|Triggering receptor expressed on myeloid cells 1 (TREM1) ATGAGGAAGACCAGGCTCTGGGGGCTGCTGTGGATGCTCTTTGTCTCAGAACTCCGAGCT GCAACTAAATTAACTGAGGAAAAGTATGAACTGAAAGAGGGGCAGACCCTGGATGTGAAA TGTGACTACACGCTAGAGAAGTTTGCCAGCAGCCAGAAAGCTTGGCAGATAATAAGGGAC GGAGAGATGCCCAAGACCCTGGCATGCACAGAGAGGCCTTCAAAGAATTCCCATCCAGTC CAAGTGGGGAGGATCATACTAGAAGACTACCATGATCATGGTTTACTGCGCGTCCGAATG GTCAACCTTCAAGTGGAAGATTCTGGACTGTATCAGTGTGTGATCTACCAGCCTCCCAAG GAGCCTCACATGCTGTTCGATCGCATCCGCTTGGTGGTGACCAAGGGTTTTTCAGGGACC CCTGGCTCCAATGAGAATTCTACCCAGAATGTGTATAAGATTCCTCCTACCACCACTAAG GCCTTGTGCCCACTCTATACCAGCCCCAGAACTGTGACCCAAGCTCCACCCAAGTCAACT GCCGATGTCTCCACTCCTGACTCTGAAATCAACCTTACAAATGTGACAGATATCATCAGG TATAGTTTCCAGGTCCCTGGGCCCCTGGTTTGGACACTGAGCCCTTTGTTTCCCAGTCTG TGTGCTGAGAGGATGTGA
- Chromosome Location
- 6
- Locus
- 6p21.1
- External Identifiers
Resource Link UniProtKB ID Q9NP99 UniProtKB Entry Name TREM1_HUMAN GenBank Protein ID 8050527 GenBank Gene ID AF196329 GeneCard ID TREM1 GenAtlas ID TREM1 HGNC ID HGNC:17760 PDB ID(s) 1Q8M, 1SMO KEGG ID hsa:54210 NCBI Gene ID 54210 - General References
- Bouchon A, Dietrich J, Colonna M: Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol. 2000 May 15;164(10):4991-5. [Article]
- Gingras MC, Lapillonne H, Margolin JF: TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development. Mol Immunol. 2002 Mar;38(11):817-24. [Article]
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details D-tartaric acid experimental unknown target Details