Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

BE0001300ProteinHumansDAPP1

May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K. It is acted on by 1 drug in DrugBank.

Gene name
DAPP1
UniProtKB entry
Q9UN19Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
280 residues · 32,193 Da
Also known as
B lymphocyte adapter protein Bam32 · B-cell adapter molecule of 32 kDa · BAM32 · hDAPP1

Resolves to

Protein
UniProtQ9UN19UniProt nameDAPP1_HUMAN
Gene
HGNCHGNC:16500NCBI Gene27071GenBank5733600GeneCardsDAPP1
Pharmacology
KEGGhsa:27071
Structure
PDB1FAOPDB1FB8
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide, and which indications are they being tested in?

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