Maltose-6'-phosphate glucosidase
Details
- Name
- Maltose-6'-phosphate glucosidase
- Kind
- protein
- Synonyms
- 3.2.1.122
- 6-phospho-alpha-D-glucosidase
- 6-phosphoryl-O-alpha-D-glucopyranosyl:phosphoglucohydrolase
- glv-1
- glvG
- malA
- Gene Name
- glvA
- UniProtKB Entry
- P54716Swiss-Prot
- Organism
- Bacillus subtilis (strain 168)
- NCBI Taxonomy ID
- 224308
- Amino acid sequence
>lcl|BSEQ0016381|Maltose-6'-phosphate glucosidase MKKKSFSIVIAGGGSTFTPGIVLMLLDHLEEFPIRKLKLYDNDKERQDRIAGACDVFIRE KAPDIEFAATTDPEEAFTDVDFVMAHIRVGKYAMRALDEQIPLKYGVVGQETCGPGGIAY GMRSIGGVLEILDYMEKYSPDAWMLNYSNPAAIVAEATRRLRPNSKILNICDMPVGIEDR MAQILGLSSRKEMKVRYYGLNHFGWWTSIQDQEGNDLMPKLKEHVSQYGYIPKTEAEAVE ASWNDTFAKARDVQAADPDTLPNTYLQYYLFPDDMVKKSNPNHTRANEVMEGREAFIFSQ CDMITREQSSENSEIKIDDHASYIVDLARAIAYNTGERMLLIVENNGAIANFDPTAMVEV PCIVGSNGPEPITVGTIPQFQKGLMEQQVSVEKLTVEAWAEKSFQKLWQALILSKTVPNA RVARLILEDLVEANKDFWPELDQSPTRIS
- Number of residues
- 449
- Molecular Weight
- 50513.14
- Theoretical pI
- 4.67
- GO Classification
- Functionsmaltose-6'-phosphate glucosidase activity / metal ion binding / oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptorProcessescarbohydrate metabolic process
- General Function
- Hydrolyzes maltose-6'-phosphate and trehalose-6'-phosphate. Is involved in the catabolism of alpha-glycosides accumulated via a phosphoenolpyruvate-dependent maltose phosphotransferase system (PEP-PTS). Is also able to significantly catalyze the hydrolysis of both 6-phospho-alpha- and 6-phospho-beta-glucosides containing activated leaving groups such as p-nitrophenol and does so with retention and inversion, respectively, of the substrate anomeric configuration.
- Specific Function
- maltose-6'-phosphate glucosidase activity
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0016382|Maltose-6'-phosphate glucosidase (glvA) ATGAAGAAAAAATCATTCTCAATCGTAATAGCGGGCGGAGGGAGCACTTTCACTCCAGGG ATCGTACTCATGCTCTTGGACCATTTGGAGGAGTTTCCGATCAGAAAGCTGAAGCTGTAT GATAATGATAAGGAGAGACAGGATCGAATTGCAGGCGCCTGTGACGTTTTTATCAGAGAA AAAGCGCCGGATATTGAATTTGCAGCGACGACTGACCCGGAAGAAGCTTTTACAGATGTC GATTTTGTTATGGCGCACATCAGAGTAGGGAAATACGCGATGCGCGCGCTTGATGAGCAA ATTCCGTTAAAGTACGGAGTTGTCGGCCAGGAGACGTGCGGGCCGGGCGGGATCGCATAC GGTATGCGTTCGATCGGCGGTGTGCTTGAAATATTAGATTACATGGAAAAATACTCGCCT GATGCGTGGATGCTCAATTATTCCAATCCGGCGGCAATTGTGGCTGAAGCTACGAGACGC CTTAGACCGAATTCTAAAATTCTCAATATCTGTGATATGCCGGTTGGGATCGAAGACCGG ATGGCGCAAATTCTTGGCTTATCCTCAAGAAAAGAAATGAAGGTCCGCTATTACGGATTG AATCATTTCGGCTGGTGGACATCGATTCAGGATCAAGAGGGCAACGATTTAATGCCGAAG CTGAAGGAACATGTATCCCAATACGGTTATATTCCGAAAACAGAGGCTGAAGCTGTGGAG GCAAGCTGGAATGACACGTTCGCCAAAGCGCGTGACGTGCAGGCTGCAGATCCTGACACA CTGCCGAATACGTATTTGCAATATTATTTGTTCCCAGATGATATGGTGAAAAAATCAAAT CCGAATCATACGCGGGCGAATGAAGTCATGGAAGGGCGCGAAGCTTTTATTTTCAGCCAA TGTGACATGATCACACGTGAACAGTCCTCGGAAAACAGCGAAATTAAAATCGATGACCAC GCATCGTATATCGTTGATCTTGCCCGGGCGATTGCCTACAACACAGGTGAAAGAATGCTG TTGATTGTTGAAAATAACGGTGCAATTGCGAACTTTGACCCGACTGCGATGGTTGAGGTG CCATGCATCGTCGGCTCAAATGGACCTGAACCGATTACCGTTGGCACCATTCCGCAATTC CAGAAAGGGCTCATGGAGCAGCAGGTATCCGTTGAGAAGCTGACTGTTGAAGCGTGGGCA GAGAAATCGTTCCAAAAGCTGTGGCAGGCGCTGATCCTGTCAAAAACAGTGCCGAACGCG CGTGTGGCAAGACTCATTCTTGAGGATTTAGTGGAGGCCAACAAAGACTTCTGGCCTGAG CTTGATCAAAGCCCAACCCGCATATCATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P54716 UniProtKB Entry Name GLVA_BACSU GenBank Protein ID 1486241 GenBank Gene ID D50543 PDB ID(s) 1U8X KEGG ID bsu:BSU08180 NCBI Gene ID 936161 - General References
- Yamamoto H, Uchiyama S, Fajar AN, Ogasawara N, Sekiguchi J: Determination of a 12 kb nucleotide sequence around the 76 degrees region of the Bacillus subtilis chromosome. Microbiology. 1996 Jun;142 ( Pt 6):1417-21. [Article]
- Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. [Article]
- Thompson J, Pikis A, Ruvinov SB, Henrissat B, Yamamoto H, Sekiguchi J: The gene glvA of Bacillus subtilis 168 encodes a metal-requiring, NAD(H)-dependent 6-phospho-alpha-glucosidase. Assignment to family 4 of the glycosylhydrolase superfamily. J Biol Chem. 1998 Oct 16;273(42):27347-56. [Article]
- Yamamoto H, Serizawa M, Thompson J, Sekiguchi J: Regulation of the glv operon in Bacillus subtilis: YfiA (GlvR) is a positive regulator of the operon that is repressed through CcpA and cre. J Bacteriol. 2001 Sep;183(17):5110-21. [Article]
- Varrot A, Yamamoto H, Sekiguchi J, Thompson J, Davies GJ: Crystallization and preliminary X-ray analysis of the 6-phospho-alpha-glucosidase from Bacillus subtilis. Acta Crystallogr D Biol Crystallogr. 1999 Jun;55(Pt 6):1212-4. [Article]
- Yip VL, Thompson J, Withers SG: Mechanism of GlvA from Bacillus subtilis: a detailed kinetic analysis of a 6-phospho-alpha-glucosidase from glycoside hydrolase family 4. Biochemistry. 2007 Aug 28;46(34):9840-52. Epub 2007 Aug 4. [Article]
- Rajan SS, Yang X, Collart F, Yip VL, Withers SG, Varrot A, Thompson J, Davies GJ, Anderson WF: Novel catalytic mechanism of glycoside hydrolysis based on the structure of an NAD+/Mn2+ -dependent phospho-alpha-glucosidase from Bacillus subtilis. Structure. 2004 Sep;12(9):1619-29. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details alpha-D-glucose 6-phosphate experimental unknown target Details