Uric acid degradation bifunctional protein

BE0001313ProteinBacillus sp. (strain TB-90)uao

Catalyzes two steps in the degradation of uric acid, i.e. the oxidation of uric acid to 5-hydroxyisourate (HIU) and the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin (By similarity). It is acted on by 2 drugs in DrugBank.

Gene name
uao
UniProtKB entry
Q45697Swiss-Prot
Residues / weight
502 residues · 57,977 Da
Also known as
4.1.1.97 · OHCU decarboxylase

Resolves to

Protein
UniProtQ45697UniProt namePUCL_BACSB
Gene
GenBank12082301
Structure
PDB1J2GPDB3WLV
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Uric acid degradation bifunctional protein, and which indications are they being tested in?

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