Deoxyuridine 5'-triphosphate nucleotidohydrolase

BE0001318ProteinMycobacterium tuberculosisdut

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. It is acted on by 4 drugs in DrugBank.

Gene name
dut
UniProtKB entry
P9WNS5Swiss-Prot
Residues / weight
154 residues · 15,803 Da
Also known as
3.6.1.23 · dUTP pyrophosphatase · dUTPase

Resolves to

Protein
UniProtP9WNS5UniProt nameDUT_MYCTU
Gene
NCBI Gene887290
Pharmacology
KEGGmtu:Rv2697c
Structure
PDB1MQ7PDB1SIXPDB1SJN
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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11+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Deoxyuridine 5'-triphosphate nucleotidohydrolase, and which indications are they being tested in?

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