Methionine aminopeptidase

Details

Name
Methionine aminopeptidase
Kind
protein
Synonyms
  • 3.4.11.18
  • MAP
  • Peptidase M
Gene Name
map
UniProtKB Entry
P0A079Swiss-Prot
Organism
Staphylococcus aureus (strain MW2)
NCBI Taxonomy ID
196620
Amino acid sequence
>lcl|BSEQ0010919|Methionine aminopeptidase
MIVKTEEELQALKEIGYICAKVRNTMQAATKPGITTKELDNIAKELFEEYGAISAPIHDE
NFPGQTCISVNEEVAHGIPSKRVIREGDLVNIDVSALKNGYYADTGISFVVGESDDPMKQ
KVCDVATMAFENAIAKVKPGTKLSNIGKAVHNTARQNDLKVIKNLTGHGVGLSLHEAPAH
VLNYFDPKDKTLLTEGMVLAIEPFISSNASFVTEGKNEWAFETSDKSFVAQIEHTVIVTK
DGPILTTKIEEE
Number of residues
252
Molecular Weight
27502.085
Theoretical pI
4.94
GO Classification
Functions
metal ion binding / metalloaminopeptidase activity
Processes
protein initiator methionine removal
General Function
Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.
Specific Function
initiator methionyl aminopeptidase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0002619|759 bp
CTATTCTTCTTCAATTTTTGTCGTTAAAATCGGACCATCCTTAGTCACGATAACCGTATG
CTCAATTTGAGCAACAAAACTTTTATCGCTCGTTTCAAAAGCCCATTCATTTTTACCTTC
TGTAACAAATGATGCATTTGATGAGATAAACGGTTCAATAGCTAATACCATACCTTCAGT
TAATAATGTTTTGTCTTTTGGATCAAAGTAATTAAGTACATGTGCTGGTGCTTCATGTAA
TGATAAACCAACACCATGACCTGTTAAGTTTTTAATGACTTTCAAATCATTTTGTCTAGC
TGTATTATGCACCGCTTTACCAATGTTACTTAACTTAGTACCCGGTTTTACTTTTGCAAT
TGCATTCTCAAATGCCATCGTTGCTACGTCACATACTTTTTGTTTCATTGGATCATCTGA
TTCTCCAACGACAAATGAAATGCCTGTATCTGCATAATAGCCATTCTTCAAAGCCGATAC
ATCAATATTTACTAAATCTCCTTCACGAATGACACGCTTACTTGGAATCCCATGTGCCAC
CTCTTCATTGACACTAATACACGTTTGACCAGGAAAATTTTCATCATGAATTGGCGCAGA
AATAGCACCGTATTCTTCAAATAACTCTTTCGCAATATTATCAAGCTCTTTCGTAGTGAT
ACCTGGTTTGGTTGCAGCTTGCATTGTATTGCGCACTTTAGCGCATATGTATCCAATTTC
TTTTAACGCTTGTAATTCTTCTTCTGTTTTTACAATCAT
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP0A079
UniProtKB Entry NameMAP1_STAAW
GenBank Protein ID21204998
GenBank Gene IDBA000033
NCBI Gene ID23197744
General References
  1. Baba T, Takeuchi F, Kuroda M, Yuzawa H, Aoki K, Oguchi A, Nagai Y, Iwama N, Asano K, Naimi T, Kuroda H, Cui L, Yamamoto K, Hiramatsu K: Genome and virulence determinants of high virulence community-acquired MRSA. Lancet. 2002 May 25;359(9320):1819-27. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
(2s)-2-Amino-4-(Methylsulfanyl)-1-Pyridin-2-Ylbutane-1,1-DiolexperimentalunknowntargetDetails
(3s)-3-Amino-1-(Cyclopropylamino)Heptane-2,2-DiolexperimentalunknowntargetDetails